Table 6.
Differences in host antiviral gene expression between influenza-positive samples and rhinovirus-positive samples
| Gene Symbol | Protein | Fold Regulation | Uncorrected P Value | FDR |
|---|---|---|---|---|
| CCL3 | C-X-C motif chemokine 3 | 2.8761 | 0.032 | 0.134 |
| CD40 | CD40, TNF receptor superfamily member 5 | 2.713 | 0.108 | 0.236 |
| CD80 | CD80/B7-1 | 3.7566 | 0.154 | 0.302 |
| CTSB | Cathepsin B | 2.3239 | 0.024 | 0.112 |
| CXCL10 | C-X-C motif chemokine 10 | −26.568 | 0.093 | 0,216 |
| CXCL11 | C-X-C motif chemokine 11 | −3.0398 | 0.468 | 0.577 |
| CXCL9 | C-X-C motif chemokine 9 | −3.7826 | 0.234 | 0.361 |
| DDX58 | Retinoic acid–inducible gene-I | 2.8931 | 0.492 | 0.588 |
| HSP90AA1 | Heat shock protein 90kDa α, class A member | 2.2825 | 0.079 | 0.195 |
| IFNAR1 | Interferon-α/β receptor α chain | 4.4748 | 0.415 | 0.548 |
| IFNB1 | Interferon, β1, fibroblast | −2.2168 | 0.439 | 0.561 |
| IL12A | IL-12A | 7.7172 | 0.121 | 0.250 |
| IL12B | IL-12B | 8.0161 | 0.002 | 0.041 |
| IRAK1 | IL-1 receptor–associated kinase 1 | 2.6623 | 0.004 | 0.049 |
| IRF5 | Interferon regulatory factor 5 | 3.3067 | 0.305 | 0.419 |
| JUN | Jun proto-oncogene | 2.0744 | 0.013 | 0.085 |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 (MEK) | 8.6054 | 0.007 | 0.070 |
| MAP2K3 | Mitogen-activated protein kinase kinase 3 (MKK3) | 2.0332 | 0.209 | 0.368 |
| MAPK14 | Mitogen-activated protein kinase 14 (p38 MAPK) | 2.0152 | 0.717 | 0.780 |
| MAPK8 | Mitogen-activated protein kinase 8/Jun N-terminal kinase (JNK) | 3.3135 | 0.573 | 0.663 |
| MAVS | Mitochondrial antiviral signaling protein | 6.0483 | 0.063 | 0.181 |
| MEFV | Pyrin | 7.5083 | 0.224 | 0.378 |
| MX1 | Myxovirus (influenza virus) resistance 1 | 12.702 | 0.603 | 0.676 |
| MYD88 | Myeloid differentiation primary response gene (88) | 5.4022 | 0.200 | 0.371 |
| NFKB1 | Nuclear factor of κ light polypeptide gene enhancer in B-cells-1/NF-κB p50 | 2.9631 | 0.018 | 0.095 |
| NFKBIA | NF-κB inhibitor, α (IκBα) | 2.0554 | 0.074 | 0.197 |
| PYDC1 | PYD (pyrin domain) containing 1 | 2.1224 | 0.230 | 0.370 |
| SPP1 | Secreted phosphoprotein 1/osteopontin | 5.0982 | 0.984 | 0.984 |
| STAT1 | Signal transducer and activator of transcription-1 | 13.6147 | 0.303 | 0.431 |
| TBK1 | TANK-binding kinase-1 | 3.2648 | 0.039 | 0.146 |
| TICAM1 | Toll-like receptor adaptor molecule 1 | 2.5642 | <0.001 | 0.010 |
| TLR8 | Toll-like receptor 8 | 2.1646 | 0.260 | 0.385 |
| TLR9 | Toll-like receptor 9 | −2.7326 | 0.861 | 0.910 |
| TNF | Tumor necrosis factor-α | 5.4128 | 0.051 | 0.174 |
| TRAF3 | TNF receptor-associated factor 3 | 2.6977 | 0.008 | 0.065 |
| TRAF6 | TNF receptor-associated factor 6 | 2.4659 | 0.052 | 0.160 |
| TRIM25 | Tripartite motif containing 25 | 3.2713 | 0.901 | 0.926 |
Definition of abbreviations: FDR = false discovery rate; TNF = tumor necrosis factor.