Table 2.
Association of pulmonary function with adiposity and metabolic measures
| Metabolic or Adiposity Measure | FEV1/FVC |
RV |
RV/TLC |
ERV |
FRC |
IC |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β* (95% CI) | P Value | β* (95% CI) | P Value | β* (95% CI) | P Value | β* (95% CI) | P Value | β* (95% CI) | P Value | β* (95% CI) | P Value | |
| HOMA-IR | −0.3 (−0.6 to −0.01) | 0.04 | −1.6 (−3.1 to −0.1) | 0.03 | −0.3 (−0.6 to −0.1) | <0.001 | −1.7 (−2.5 to −0.9) | <0.001 | −1.5 (−2.3 to −0.7) | <0.001 | 1 (0.4 to 1.6) | 0.001 |
| HDL | 0.2 (0.1 to 0.3) | 0.002 | 0.6 (0.04 to 1.1) | 0.03 | 0.2 (0.1 to 0.3) | <0.0001 | −0.1 (−0.4 to 0.2) | 0.7 | 0.2 (−0.1 to 0.5) | 0.1 | −0.4 (−0.6 to −0.2) | <0.001 |
| BMI z-score | −1.1 (−2.2 to 0.02) | 0.05 | −15.1 (−20.4 to −9.8) | <0.0001 | −3 (−3.9 to −2.1) | <0.0001 | −6.2 (−9.4 to −3.1) | <0.001 | −9.5 (−12.2 to −6.7) | <0.0001 | 6.2 (3.9 to 8.4) | <0.0001 |
| WC, cm | −0.1 (−0.2 to −0.03) | 0.004 | −0.8 (−1.2 to −0.5) | <0.0001 | −0.2 (−0.2 to −0.1) | <0.0001 | −0.4 (−0.6 to −0.2) | <0.0001 | −0.6 (−0.7 to −0.4) | <0.0001 | 0.4 (0.3 to 0.5) | <0.001 |
Definition of abbreviations: BMI = body mass index; CI = confidence interval; ERV = expiratory reserve volume; HDL = high-density lipoprotein; HOMA-IR = homeostatic model assessment of insulin resistance; IC = inspiratory capacity; WC = waist circumference.
*
β denotes the change in each pulmonary function index (percent predicted or percent) with a unit increase in metabolic measures (HOMA-IR and HDL) or adiposity measures (BMI z-score and waist circumference).