Table 1.
Baseline characteristics of derivation and validation cohorts by acute respiratory distress syndrome diagnosis
| Characteristic | Derivation Cohort |
Validation Cohort |
||||
|---|---|---|---|---|---|---|
| ARDS (n = 189; 30%) | Not ARDS (n = 447; 70%) | P Value | ARDS (n = 205; 34%) | Not ARDS (n = 404; 66%) | P Value | |
| Demographics | ||||||
| Age, yr | 37 (23–50) | 33 (24–48) | 0.741 | 44 (27–58) | 43 (28–56) | 0.922 |
| Male sex | 148/188 (79%) | 348/447 (78%) | 0.808 | 149/205 (73%) | 297/404 (74%) | 0.827 |
| Race | 0.567 | 0.808 | ||||
| African American | 88/186 (47%) | 234/441 (53%) | 26/205 (13%) | 59/404 (15%) | ||
| White | 94/186 (51%) | 197/441 (45%) | 171/205 (83%) | 329/404 (81%) | ||
| Other race | 4/186 (2%) | 10/441 (3%) | 8/205 (4%) | 16/404 (4%) | ||
| Severity of illness | ||||||
| ISS | 25 (20–29) | 22 (18–27) | 0.003 | 33 (25–41) | 26 (19–34) | <0.001 |
| Etiology of injury | ||||||
| Blunt | 138/189 (73.0%) | 298/446 (66.8%) | 0.124 | 188/205 (92%) | 339/404 (84%) | 0.008 |
| Penetrating | 51/189 (27.0%) | 148/446 (33.2%) | 17/205 (8%) | 65/404 (16%) | ||
| Transfusions | ||||||
| RBC, units | 2 (0–7) | 0 (0–4) | <0.001 | 2 (0–6) | 1 (0–4) | 0.003 |
| FFP, units | 0 (0–4) | 0 (0–2) | <0.001 | 2 (0–4) | 0 (0–4) | 0.015 |
| Mortality | 45/189 (23.8%) | 29/447 (6.5%) | <0.001 | 26/205 (13%) | 45/404 (11%) | 0.575 |
Definition of abbreviations: ARDS = acute respiratory distress syndrome; FFP = fresh frozen plasma; ISS = Injury Severity Score; RBC = red blood cells.
Values represent median and interquartile range or number and percentage. Distributions of continuous variables were compared using a Wilcoxon rank-sum test and categorical variables using a Pearson chi-square test.