Table 4.

Plasma biomarker levels by acute respiratory distress syndrome onset class

Biomarker	Early-Onset ARDS (n = 66; 59%)	Late-Onset ARDS (n = 46; 41%)	P Value
IL-8, pg/ml	15.6 (15.6–58.2)	15.6 (15.6–85.5)	0.644
VWF, % control	231 (168–351)	248 (194–353)	0.219
SP-D, ng/ml	57 (37–88)	63 (42–80)	0.927
PAI-1, ng/ml	138 (40–266)	87 (40–197)	0.271
CC16, ng/ml	6.9 (4.1–12.4)	5.8 (4.4–8.3)	0.187
sRAGE, pg/ml	1,773 (949–3,227)	1,226 (773–1,944)	0.025
Ang-2, pg/ml	5,684 (4,190–7,773)	4,365 (2,957–5,647)	0.002
BNP, ng/ml	0.41 (0.31–0.67)	0.33 (0.26–0.56)	0.123
PCP III, ng/ml	3.5 (2.8–4.9)	3.2 (2.7–4.2)	0.249
IL-10, pg/ml	16 (9–86)	21 (9–70)	0.703
TNF-α, pg/ml	1.03 (0.61–3.47)	0.67 (0.61–4.83)	0.535

Definition of abbreviations: Ang-2 = angiopoietin-2; BNP = brain natriuretic peptide; PAI-1 = plasminogen activator inhibitor-1; PCP III = procollagen peptide type III; SP-D = surfactant protein D; sRAGE = soluble receptor for advanced glycation end-products; TNF-α = tumor necrosis factor-α; VWF = von Willebrand factor.

Values represent medians and interquartile ranges. Classes were compared using the Wilcoxon rank sum test.