Table 5.
| |||
---|---|---|---|
Entry | Ar–Br | Pd(OAc)2 (mol%)/NIXANTPHOS (mol%) | Yield (%) |
1 | 5/7.5 | 90 (3ag) | |
2 | 5/7.5 | 92 (3ab) | |
3 | 5/7.5 | 63 (3ae) |
Reactions conducted on a 0.1 mmol scale using 3 equiv. of benzyl amine, 3 equiv. of benzophenone imine, 3 equiv. of NaN(SiMe3)2, and 1 equiv. of aryl bromide at 0.1 M. Base was added portionwise at 0.1 mL per 30 min.
Isolated yield after chromatographic purification.