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. 1972 Oct;6(4):610–615. doi: 10.1128/iai.6.4.610-615.1972

Identification and Quantitation of Equine Serum and Secretory Immunoglobulin A

T C McGuire 1, T B Crawford 1
PMCID: PMC422582  PMID: 4117801

Abstract

Immunoglobulin A (IgA) was demonstrated in equine serum and secretions. This immunoglobulin had a molecular weight extending from 150,000 to 700,000 and reacted with specific antihuman alpha-chain antiserum. Antigenic determinants specific for secretory IgA were demonstrated and found to be absent on serum IgA. Antigen binding activity was detected in IgA from tears. Purified IgA was antigenically distinct from equine IgG, IgM, IgG(T), and aggregating immunoglobulin. Quantitative studies demonstrated that IgA was the predominant immunoglobulin in tears and milk but not in colostrum. The electrophoretic mobility, size, presence of secretory component, and reaction with specific antihuman alpha-chain antiserum demonstrates that this immunoglobulin is the equine homologue of human IgA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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