Table 2.

Scoring criteria of the histopathology of the brain.

Score	Degeneration	Amyloid disorders		Tauopathy
		CAA	Senile plaques
1	Condensed chromatin inside nuclei (chromatolysis)	Deposit of amyloid in vascular wall of arterioles	Diffused plaques – appearing as small numbers of nodules in the brain parenchyma	p-tau detected inside the cytoplasm of the neuron (intracellular stage)
2	Aggregation of satellite cell/glial cell (gliosis)	Deposit of amyloid in vascular wall of venules	Compacted plaques – appearing in larger amounts and sizes in the brain parenchyma	p-tau detected in the cytoplasm and/or axon of the neuron (fibrillar stage)
3	Formation of vacuole sites as indicative of active phagocytosis of the degenerated neuron (vacuolization)	Deposit of amyloid in vascular wall of capillaries	Compacted plaques in the brain parenchyma associated with degeneration of the surrounding nerve	p-tau detected as tangled formations outside of the neuron (extracellular stage)