Table 3.
Adiposity Indicators and Lung Function, Stratified by Current Asthma and FeNO Level
| BMI z Score | PBF z Score | WC z Score | |
|---|---|---|---|
| FeNO < 20 ppb | |||
| No asthma (n = 1,973) | |||
| FEV1, ml* | 64.61 (42.77 to 86.46)† | 27.76 (3.50 to 52.02)‡ | 49.22 (21.20 to 77.25)† |
| FVC, ml* | 112.48 (90.42 to 134.54)† | 65.84 (42.27 to 89.41)† | 111.84 (81.23 to 142.45)† |
| FEV1/FVC, % | −0.98 (−1.27 to −0.67)† | −0.92 (−1.28 to −0.56)† | −1.27 (−1.71 to −0.83)† |
| Asthma (n = 86) | |||
| FEV1, ml* | 59.36 (12.34 to 106.38)‡ | 33.67 (−31.34 to 98.68) | 34.22 (−44.68 to 113.11) |
| FVC, ml* | 89.26 (34.81 to 143.72)† | 35.91 (−46.91 to 120.74) | 63.71 (−24.68 to 152.10) |
| FEV1/FVC, % | −0.42 (−1.51 to 0.67) | −0.09 (−1.23 to 1.05) | −0.66 (−1.74 to 0.43) |
| FeNO ≥ 20 ppb | |||
| No asthma (n = 537) | |||
| FEV1, ml* | 110.89 (70.27 to 151.51)† | 92.38 (51.02 to 133.73)† | 121.36 (69.23 to 173.50)† |
| FVC, ml* | 186.02 (136.93 to 235.11)† | 150.67 (98.69 to 202.65)† | 206.33 (136.93 to 275.74)† |
| FEV1/FVC, % | −1.31 (−1.84 to −0.79)† | −1.14 (−1.82 to −0.46)† | −1.28 (−1.95 to −0.61)† |
| Asthma (n = 85) | |||
| FEV1, ml* | −57.88 (−154.75 to 38.99) | −56.43 (−161.65 to 48.39) | −56.80 (−173.38 to 59.78) |
| FVC, ml* | −4.08 (−115.80 to 107.64) | −11.12 (−136.27 to 114.03) | −2.19 (−155.65 to 151.26) |
| FEV1/FVC, % | −1.67 (−2.93 to −0.42)† | −1.54 (−2.94 to −0.14)‡ | −1.54 (−2.93 to −0.15)‡ |
Definition of abbreviations: BMI = body mass index; FeNO = fractional exhaled nitric oxide; PBF = percent body fat; WC = waist circumference.
Results shown as beta coefficient (95% confidence interval) per 1.0 z score increment in each adiposity measure. All models adjusted for age, sex, race and ethnicity, family history of asthma, annual household income, use of oral or inhaled steroids, and environmental tobacco smoke exposure.
*
Analyzed as absolute values; adjusted additionally for height and height squared.
†
P < 0.01.
‡
P < 0.05.