Table 2.

Univariate models for progression to invasive disease/radical cystectomy or to muscle-invasive disease/radical cystectomy in 155 patients (unless otherwise indicated)

	Progression to invasive disease (≥cT1) or radical cystectomy			Progression to muscle- invasive disease (≥cT2) or radical cystectomy
	HR	95% CI	P value	HR	95% CI	P value
Male	0.654	0.379, 1.13	0.13	0.698	0.389, 1.25	0.2
Age (per 10-yr increase)	1.02	0.827, 1.27	0.8	1.04	0.828, 1.31	0.7
Race (white non-Hispanic vs. all others)	0.810	0.328, 2.00	0.6	0.739	0.298, 1.83	0.5
Smoking history (n=146)			0.9			0.5
None	Ref	Ref		Ref	Ref
Current	0.860	0.351, 2.11		0.536	0.183, 1.57
Former	1.02	0.629, 1.66		1.02	0.608, 1.71
Presenting symptoms			0.067			0.19
Asymptomatic, micro-hematuria	Ref	Ref		Ref	Ref
Gross hematuria	1.83	0.988, 3.38		1.89	0.986, 3.63
Voiding symptoms (irritative or obstructive)	2.29	1.21, 4.32		1.94	0.975, 3.87
Unknown	1.40	0.668, 2.91		1.36	0.621, 2.97
CIS pattern (n=120)			0.4			0.9
Focal	Ref	Ref		Ref	Ref
Multiple	1.05	0.626, 1.78		1.03	0.598, 1.79
Diffuse	1.69	0.779, 3.66		1.25	0.527, 2.94
BCG responder (n=130)*	0.587	0.363, 0.947	0.029	0.532	0.320, 0.884	0.015

^*25 patients who progressed within 6 mo of BCG therapy or were not followed for 6 mo were excluded.