Table 2.
Progression to invasive disease (≥cT1) or radical cystectomy | Progression to muscle- invasive disease (≥cT2) or radical cystectomy | |||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Male | 0.654 | 0.379, 1.13 | 0.13 | 0.698 | 0.389, 1.25 | 0.2 |
Age (per 10-yr increase) | 1.02 | 0.827, 1.27 | 0.8 | 1.04 | 0.828, 1.31 | 0.7 |
Race (white non-Hispanic vs. all others) | 0.810 | 0.328, 2.00 | 0.6 | 0.739 | 0.298, 1.83 | 0.5 |
Smoking history (n=146) | 0.9 | 0.5 | ||||
None | Ref | Ref | Ref | Ref | ||
Current | 0.860 | 0.351, 2.11 | 0.536 | 0.183, 1.57 | ||
Former | 1.02 | 0.629, 1.66 | 1.02 | 0.608, 1.71 | ||
Presenting symptoms | 0.067 | 0.19 | ||||
Asymptomatic, micro-hematuria | Ref | Ref | Ref | Ref | ||
Gross hematuria | 1.83 | 0.988, 3.38 | 1.89 | 0.986, 3.63 | ||
Voiding symptoms (irritative or obstructive) | 2.29 | 1.21, 4.32 | 1.94 | 0.975, 3.87 | ||
Unknown | 1.40 | 0.668, 2.91 | 1.36 | 0.621, 2.97 | ||
CIS pattern (n=120) | 0.4 | 0.9 | ||||
Focal | Ref | Ref | Ref | Ref | ||
Multiple | 1.05 | 0.626, 1.78 | 1.03 | 0.598, 1.79 | ||
Diffuse | 1.69 | 0.779, 3.66 | 1.25 | 0.527, 2.94 | ||
BCG responder (n=130)* | 0.587 | 0.363, 0.947 | 0.029 | 0.532 | 0.320, 0.884 | 0.015 |
25 patients who progressed within 6 mo of BCG therapy or were not followed for 6 mo were excluded.