Fig. 2.

Solution structures of L_M(0P/1P/2P). (A, C, and E) The 10 lowest-energy states for L_M0P, L_M1P, and L_M2P as free solution structures are shown. These ensembles are as deposited with PDB. (B, D, and F) The state-1, lowest energy structure for each protein is labeled with determined motifs. (G) Superimposition of the zinc-finger regions of L_M0P and L_M1P highlight observed rearrangements. (H) Similarly, superimposition of L_M1P and L_M2P zinc finger regions show conformational changes centering on the zinc binding domain, particularly H₁₆. In all panels, the zinc ion is a gray sphere.