Table 1.

NMR restraints and structural statistics

Measurements	LM0P	LM1P	LM2P	(RAN): LM0P	Ran: (LM0P)
Total distance restraints	256	129	353	397	600
Number of torsion angle dynamics steps	5,000	5,000	5,000	5,000	5,000
Number of structures initial: 50	Final: 10	Final: 10	Final: 10	Final: 10	Final: 10
Hydrogen bonds	42	62	75	76	364
Total dihedral angle restraints	62	90	90	94	154
ɸ	31	45	45	47	77
ψ	31	45	45	47	77
Restraint violations
Distance restraint violation > 0.2 Å	None	None	None	None	None
Angle restraint violation > 5.0°	None	1	None	None	5
Average RMSD (Å) among the 10 refined structures
Residues	1–71	1–71	1–71	1–71	1–216
Backbone residues	2.0	1.2	3.1	1.0	4.8
Ramachandran statistics of 10 structures (% residues)
Most favored regions	94.2	98.4	96.8	98.6	94.4
Additional allowed regions	5.8	1.6	3.2	0	2.8
Disallowed regions	0	0	0	1.4	2.8

All values were generated by CYANA for structure determination before Xplor-NIH refinement. Reported RMSD values rounded to 0.1 Å.