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. 2014 Oct 22;111(44):E4697–E4705. doi: 10.1073/pnas.1413128111

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Fig. 1. — Coq9^R239X mice have decreased steady-state levels of CoQ biosynthesis proteins. (A) Coq9^R239X truncation scheme designed by García-Corzo et al. (11). (B) Experimental design for proteomic LC-MS/MS analysis of WT and Coq9^R239X mice tissue (heart, kidney, cerebellum with n = 3 for each tissue). (C) Volcano plot of protein abundance (•) changes between WT and Coq9^R239X mouse heart [Fold Δ Log₂(Coq9^R239X/WT) versus –Log₁₀(P value)] with COQ proteins labeled. (D) COQ protein abundance changes between WT and Coq9^R239X in () heart, (■) kidney, and () cerebellum [Fold Δ Log₂(Coq9^R239X/WT)] with error bars showing standard deviation. See also Fig. S1.

Inline graphic — Coq9^R239X mice have decreased steady-state levels of CoQ biosynthesis proteins. (A) Coq9^R239X truncation scheme designed by García-Corzo et al. (11). (B) Experimental design for proteomic LC-MS/MS analysis of WT and Coq9^R239X mice tissue (heart, kidney, cerebellum with n = 3 for each tissue). (C) Volcano plot of protein abundance (•) changes between WT and Coq9^R239X mouse heart [Fold Δ Log₂(Coq9^R239X/WT) versus –Log₁₀(P value)] with COQ proteins labeled. (D) COQ protein abundance changes between WT and Coq9^R239X in () heart, (■) kidney, and () cerebellum [Fold Δ Log₂(Coq9^R239X/WT)] with error bars showing standard deviation. See also Fig. S1.