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. 2014 Oct 20;111(44):15810–15815. doi: 10.1073/pnas.1415219111

Fig. 4.

Fig. 4.

Effects of running on neurotrophic factors. The brain samples collected from adipo−/− mice or WT littermates receiving the 2-wk running or nonrunning treatment as described in Fig. 2A were homogenized and subjected to immunoassays. (A and B) Running significantly increased the hippocampal but not circulating adiponectin levels in WT mice. *P < 0.05 vs. WT nonrunners. Note that adiponectin was undetectable in either the serum or hippocampal lysate of Adipo−/− mice. (C and D) The levels of BDNF in the whole hippocampus were unaffected by either exercise or adiponectin knockout. Running raised the BDNF levels specifically in the dentate gyrus of WT and adipo−/− mice essentially to the same extent. (E and F) adipo−/− mice showed lower protein levels of IGF-1 in the whole hippocampus compared with WT animals (*main effect of genotype: P < 0.001), whereas IGF-1 levels in the dentate region remained comparable in all four groups. n = 4–6 mice per group.