Fig. 3.
Reduced TgMAPK1 expression decreases parasite tissue burden independent of serum IFN-γ; (a) WT (n=10) or IFN-γ KO (n=5) mice were challenged intraperitoneally with 1,000 TgMAPK1con (con) or TgMAPK1lo (lo) tachyzoites and sacrificed one week later. Parasite burden by qPCR was compared using mixed-effects methods with the R package “nlme” (Pinheiro et al., 2008) adjusted for variations; (b) serum IFN-γ and IL-10 from mice in panel (a). Control serum from a naïve (uninf.) mouse is shown for comparison. Symbols represent individual mice.