Table 5.
Maternal serum levels of the validated PE biomarkers
|
Analyte |
PE trend |
Unit |
Early stage |
Late stage |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Normal |
PE |
Normal |
PE |
|||||||
|
Median |
Mean |
Median |
Mean |
Median |
Mean |
Median |
Mean |
|||
| (IQR) | (SD) | (IQR) | (SD) | (IQR) | (SD) | (IQR) | (SD) | |||
| PIGF |
↓ |
pg/ml |
413.8 |
529.4 |
97.5 |
115.5 |
222.279 |
238.1095 |
184.488 |
202.6929 |
| (224.9, 685.2) |
(432.0) |
(51.6, 190.7) |
(83.0) |
(163.6, 289.9) |
(111.5) |
(113.2, 223.8) |
(132.7) |
|||
| sFlt-1 |
↑ |
pg/ml |
1697.9 |
3034.0 |
19841.3 |
18646.3 |
5610.460 |
5531.241 |
14216.20 |
14414.28 |
| (1128.2, 4273.9) |
(2578.7) |
(15728.4, 21608.6) |
(3582.5) |
(4191.8, 6735.8) |
(1811.9) |
(12347.6, 19749.3) |
(5575.3) |
|||
| HPX |
↑ |
ug/ml |
1071.2 |
984.1 |
1382.8 |
1580.7 |
954.4 |
894.15 |
1482.0 |
1347.624 |
| (692.4, 1301.0) |
(388.3) |
(1173.6, 1787.0) |
(546.5) |
(538.0, 1131.6) |
(331.5) |
(1013.6, 1654.4) |
(585.3) |
|||
| ADAM12 |
↑ |
pg/ml |
511.3 |
584.0 |
775.0 |
920.2 |
666.4185 |
703.6862 |
883.889 |
1345.369 |
| (437.7, 642.3) |
(275.8) |
(637.2, 1150.2) |
(416.4) |
(594.9, 791.8) |
(217.2) |
(626.7, 1367.6) |
(1472.5) |
|||
| APO C-III |
↓ |
ng/ml |
341.3 |
364.7 |
419.2 |
486.3 |
291.58 |
321.8587 |
453.789 |
585.7512 |
| (249.5, 422.4) |
(153.4) |
(357.3, 575.5) |
(187.5) |
(240.7, 345.7) |
(126.7) |
(308.9, 725.8) |
(413.1) |
|||
| HP |
↓ |
ug/ml |
1624.1 |
1718.0 |
1181.6 |
1482.7 |
1806.74 |
1750.72 |
985.616 |
1510.514 |
| (1216.0, 2274.1) |
(764.1) |
(684.6, 1794.1) |
(1284.6) |
(1190.1, 2163.1) |
(684.1) |
(592.0, 1880.8) |
(1515.0) |
|||
| A2M |
↓ |
ug/ml |
5796.4 |
5729.1 |
3365.1 |
4259.3 |
8141.38 |
7754.764 |
3435.427 |
4340.768 |
| (3501.2, 7737.6) |
(3064.1) |
(2648.3, 9959.0) |
(2175.8) |
(5300.6, 10234.1) |
(3265.1) |
(2343.7, 6752.9) |
(2862.5) |
|||
| APO-E |
↓ |
ug/ml |
290.6 |
364.4 |
138.8 |
215.9 |
398.0 |
377.9 |
147.2 |
150.0235 |
| (104.2, 519.0) |
(301.5) |
(63.0, 210.4) |
(257.6) |
(125.0, 478.4) |
(236.3) |
(60.4, 190.0) |
(107.7) |
|||
| APO A-I |
↓ |
ng/ml |
7980.1 |
8337.7 |
4945.356 |
4708.5 |
6253.298 |
6748.614 |
4724.142 |
5483.643 |
| (5775.7, 11076.6) |
(3158.7) |
(3892.8, 5824.6) |
(1707.1) |
(5624.1, 7881.8) |
(2287.6) |
(3138.6, 7075.3) |
(3794.9) |
|||
| RBP4 |
↓ |
ng/ml |
38255.0 |
35180.4 |
38899.0 |
36931.7 |
41616.5 |
49253.5 |
33179 |
33897.47 |
| (29018.5, 40955.5) |
(7031.1) |
(33460.5, 39895.0) |
(7307.5) |
(38830.5, 44429.5) |
(38081.6) |
(29558, 37386) |
(8499.8) |
|||
| pikachurin |
↓ |
ng/ml |
601.8 |
659.1 |
293.261 |
327.8 |
536.551 |
536.551 |
317.657 |
317.657 |
| (563.8, 792.1) | (152.0) | (267.4, 367.8) | (117.5) | (459.2, 626.6) | (952.3) | (266.8, 409.7) | (623.5) | |||
IQR: interquartile range; PE: preeclampsia; SD: standard deviation.