Table 3.
Prevalence of CR1 alleles and genotypes at four loci; Kn, McC, Sl and KCAM
| Frequency of the genotypes n (%) | Controls (n = 275) | Uncomplicated malaria (n = 89) | Severe anaemia (n = 57) | Cerebral malaria (n = 121) | |
|---|---|---|---|---|---|
|
Kn
a/b
|
a/a |
275 (100) |
88 (98.9) |
57 (100) |
120 (99.2) |
| SNP Rs41274768 |
a/b |
0 (0) |
1 (1.1) |
0 (0) |
1 (0.8) |
| |
b/b |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
|
Allele frequency Kn
b
|
|
0.0 |
0.006 |
0.0 |
0.004 |
|
McC
a/b
|
a/a |
147 (53.5) |
52 (58.4 %) |
30 (52.6) |
68 (56.2) |
| SNP Rs17047660 |
a/b |
109 (39.6) |
26 (29.2) |
21 (36.8) |
42 (34.7) |
| |
b/b |
19 (6.9) |
11 (12.4) |
6 (10.5) |
11 (9.1) |
|
Allele frequency McC
b
|
|
0.27 |
0.27 |
0.29 |
0.27 |
|
Sl1/Sl2 |
1/1 |
15 (5.5) |
2 (2.2) |
5 (8.8) |
8 (6.6) |
| SNP Rs17047661 |
1/2 |
74 (26.9) |
14 (15.7) |
13 (22.8) |
24 (19.8) |
| |
2/2 |
186 (67.6) |
73 (82.0) |
39 (68.4) |
89 (73.6) |
|
Allele frequency Sl2 |
|
0.81 |
0.90 |
0.80 |
0.83 |
|
KCAM
+/-
|
+/+ |
5 (1.8) |
0 (0) |
0 (0) |
0 (0) |
| SNP Rs6691117 |
+/- |
45 (16.4) |
10 (11.2) |
8 (14.0) |
24 (19.8) |
| |
-/- |
225 (81.8) |
79 (88.8) |
49 (86.0) |
97 (80.2) |
| Allele frequency KCAM - | 0.90 | 0.94 | 0.93 | 0.90 | |
Prevalence of the alleles and genotypes at the four loci, Kn, McC, Sl and KCAM, determined in a Ghanaian population, divided in four groups; controls (CC), uncomplicated malaria (UM), severe anaemia (SA) and cerebral malaria (CM).
a/b, 1/2 and +/– denotes the alleles at the four loci.