Table 5.
Haplotype frequencies of the four SNPs in the CR1 gene, determined in Ghanaian and Brazilian study populations
| Disease group (alleles) |
Haplotype definitions |
|||||||
|---|---|---|---|---|---|---|---|---|
| H1 Kn a McC a Sl1 KCAM + | H2 Kn a McC a Sl1 KCAM - | H3 Kn a McC a Sl2 KCAM - | H4 Kn a McC b Sl1 KCAM - | H5 Kn a McC b Sl2 KCAM - | H6 Kn a McC b Sl2 KCAM + | H7 Kn a McC a Sl2 KCAM + | H8 Kn b McC a Sl1 KCAM - | |
|
Controls (n = 448) |
0.02 |
0.10 |
0.59 |
0.00 |
0.24 |
0.01 |
0.03 |
0.00 |
|
Uncomplicated malaria (n = 163) |
0.01 |
0.07 |
0.63 |
0.00 |
0.28 |
0.00 |
0.02 |
0.00 |
|
Severe anaemia (n = 98) |
0.04 |
0.11 |
0.56 |
0.00 |
0.28 |
0.00 |
0.01 |
0.00 |
|
Cerebral malaria (n = 205) |
0.03 |
0.08 |
0.60 |
0.00 |
0.25 |
0.00 |
0.03 |
0.00 |
|
Ghana (n = 914) |
0.02 |
0.09 |
0.60 |
0.00 |
0.25 |
0.003 |
0.03 |
0.00 |
|
African Brazilians
1
(n = 86) |
0.14 |
0.15 |
0.42 |
0.12 |
0.07 |
0.070 |
0.023 |
0.11 |
|
European Brazilians
1
(n = 66) |
0.73 |
0.15 |
0.015 |
0.00 |
0.015 |
0.00 |
0.00 |
0.015 |
| Asian Brazilians 1 (n = 84) | 0.79 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
1Covas et al.[27] SNPs at the four loci Kn, McC, Sl and KCAM can define eight different haplotypes. There was no difference between the disease groups in the Ghanaian population with H3 and H5 having the highest frequencies, while H4 and H8 were not found. The Ghanaian groups were also compared to the three Brazilian populations. All differed significantly from Ghana p < 0.001. When constructing the haplotypes, individuals heterozygote at more than one locus was excluded from the analysis (15 %, n = 82).
a/b, 1/2 and +/– denotes the alleles at the four loci.