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. 2014 Oct 14;5(21):3781–3786. doi: 10.1021/jz502030e

Figure 1.

Figure 1

(A) Position of the furan within dsDNA relative to the latch constriction during dsDNA residence for the duplexes 9F and 13F. (B) Replacing the C/G base pair situated at the latch constriction with a furan (abasic site analogue) opposite G increases the ion flux through αHL. (C) Representative I–t trace indicating the change in current from the open channel during dsDNA residence events. (D) Expanded view of the trace outlined in the blue box region in (C) showing the difference in blocking current between duplexes with a furan situated inside (9F) and outside of the latch region (13F). Experiments were carried out at 25 °C in a 1.00 M KCl solution buffered to pH 7.5 using 10 mM phosphate.