Figure 5.

Illustrative results for an off-lattice case, assuming attractive hydrophobic patches with the strength of patch–patch attractions scaling with the surface area of a patch (∼0.25 cal mol^–1 nm^–2). (A) comparison of the contributions to B₂₂ from the magnitude of the attraction γ_a (dashed line) and the entropic penalty for aligning patches, −kT ln f (solid curves) for a tetrahedral patch geometry akin to that in ref (46). (B) Effects of changing the number of patches N_p (main panel) and protein diameter σ (inset) for the dependence of B₂₂/B_22,S on the area of a patch for the off-lattice model, assuming λ is based on an annulus width of 0.5 nm in Figure 2. The inset is for N_p = 4, with axis labels identical to the main panel.