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. 2013 Nov 27;33(1):104–120. doi: 10.1080/07391102.2013.855142

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© 2014 The Author(s). Published by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — NA folds of (A) Tetrameric iNA with iNA-specific insertions highlighted in red (insertion before D151) and gray (Ca²⁺ ion binding site). (B) Bacterial NA of C. perfringens (non-iNA Cp) with the non-catalytical domain in green. (C) Respective active sites with ligands (gray) zanamivir in iNA (blue) and non-iNA Cp (pink). Six conserved active site residues are shown in stick representation. Structures of NAs from further investigated systems are shown in Figure S1.