Table 2.

All-cause and cardiovascular-specific deaths and SMRs by cohort after 7 years of followup^*

	No. of observed deaths				SMR (95% CI)
	EIA	2010 RA criteria positive	2010 RA criteria negative	RF/ACPA positive	EIA	2010 RA criteria positive	2010 RA criteria negative	RF/ACPA positive
All cause
Cohort 1	141	91	28	55	1.21 (1.02–1.41)	1.18 (0.96–1.45)	0.99 (0.69–1.44)	1.54 (1.18–2.00)
Cohort 2	123	75	36	44	1.17 (0.98–1.40)	1.30 (1.04–1.63)	0.89 (0.64–1.23)	1.25 (0.93–1.68)
Cohort 3	82	44	25	36	1.06 (0.85–1.32)	1.19 (0.89–1.60)	0.84 (0.57–1.24)	1.39 (1.00–1.92)
Total	346	210	89	135	1.16 (1.04–1.29)	1.22 (1.07–1.40)	0.90 (0.73–1.11)	1.39 (1.18–1.65)
Cardiovascular
Cohort 1	58	36	9	29	1.16 (0.90–1.50)	1.11 (0.80–1.54)	–*	1.87 (1.30–2.69)
Cohort 2	45	26	15	12	1.07 (0.80–1.43)	1.13 (0.77–1.66)	0.92 (0.55–1.52)	–*
Cohort 3	29	15	9	10	1.02 (0.71–1.47)	1.19 (0.72–1.98)	–*	–*
Total	132	77	33	51	1.09 (0.92–1.30)	1.13 (0.91–1.42)	0.85 (0.60–1.19)	1.31 (1.00–1.73)

^*SMR = standardized mortality ratio; 95% CI = 95% confidence interval; EIA = early inflammatory arthritis; RA = rheumatoid arthritis; RF = rheumatoid factor; ACPA = anti–citrullinated protein antibody.

^†Too few events to calculate the SMR.