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. Author manuscript; available in PMC: 2014 Nov 10.
Published in final edited form as: Subcell Biochem. 2012;65:225–251. doi: 10.1007/978-94-007-5416-4_10

Figure 10.5.

Figure 10.5

Sketches of the proposed polyglutamine fibril model derived from solid-state NMR data. An approximate scale bar is indicated at the top. Minimal repeat units of (a) polyQ15, (b) polyQ38, and (c) polyQ54 fibrils, assuming similar β-strand lengths, viewed down the fibril axis. (d) Illustration of the superpleated antiparallel cross-β arrangement of monomers in polyQ38 fibrils, viewed down the fibril axis. The fibril repeat unit consists of one GK2Q38K2 molecule that forms two β-strands and contributes to two stacked β-sheets. (Reproduced with permission from Schneider et al. 2011)