Figure 9. Least-squares solutions for model parameters in case 2 of Table 3 are shown for comparison to the selected model with 95% confidence intervals for four patient groups: Non-CF (NCF), CF HS, CF IS, and Pediatric CF (CP).

(A) MCC rate constant (kLT) (min-1) reiterates that kLT is the same in all groups. (B) Fraction (FFCA) of large airway with functional MCC. (C) Peripheral lung absorptive rate constant (kDB) (min-1) and (D) large airway absorptive rate constant (kLB) are nearly identical to their analogs in the selected model. (E) MCC rate constant (kDL) (min-1) from D to L is clearly unidentifiable, and the nominal value is much smaller than kLT in each group. Confidence intervals are also widened in all parameters directly related to MCC.