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. 2014 Jul 9;177(2):373–380. doi: 10.1111/cei.12298

Fig. 2.

Fig. 2

CD4 knock-out mice develop autoimmune cholangitis following immunization with 2-octynoic acid conjugated bovine serum albumin (2-OA–BSA). CD4−/− and CD4+/+ mice were immunized with either 2-OA–BSA/phosphate-buffered saline (PBS) or 2-OA–BSA/α-galactosylceramide (α-GalCer) and killed at week 12. (a) Liver total mononuclear cells (MNCs); (b) numbers of natural killer (NK) T (CD3+NK1.1+), NK (CD3−NK1.1+), T (CD3+ NK1.1−) excluding CD4+ T and B (CD19+) cells; (c) numbers of CD4−CD8+ and CD4−CD8− T cells; (d) number of γδ T cells were determined by flow cytometry. Results are expressed as mean ± standard error of the mean (s.e.m.); n = four to 16 per group. *P < 0·05; **P < 0·01; ***P < 0·005.