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[Nle4, DPhe7]-α-MSH (NDP-MSH treatment attenuated the development of arthritis in lupus mice (LM) induced by pristane. LM treated with NDP-MSH (LM-MSH group) presented significant reduction of arthritis score. Severity of arthritis was assessed using a scoring system that considers oedema, erythema and number of affected joints as: 1 = small, 2 = moderate, 3 = marked and 4 = severe. Results are expressed as raw data with median; *P < 0·05 versus control and #P < 0·05 versus LM.
