Fig. 5.

[Nle4, DPhe7]-α-MSH (NDP-MSH treatment limited renal lesion in pristane-induced lupus-like model. The analysis of glomerular cellularity and renal damage scores, assessed in periodic acid-Schiff (PAS)-stained sections, graded as: 1+ = mild focal mesangial hypercellularity; 2+ = moderate mesangial hypercellularity; 3+ = complex endocapillary hypercellularity sometimes with mild sclerosis or necrosis; 4+ = severe endocapillary proliferative glomerulonephritis, revealed an amelioration of these parameters in LM treated with NDP-MSH. The results are expressed as median with interquartile range, *P < 0·05 versus control and #P < 0·05 compared to the LM.