Figure 1.

A, Experimental protocols. The lungs were either ventilated and perfused for 140 minutes (control) or subjected to 20 minutes of equilibration, followed by deflation (60 minutes) and reinflation (60 minutes) in the absence (D/R) or presence of inhibitors (D/R+inhibitor). The samples were collected at the points indicated. B, Effects of lung deflation and reinflation on dynamic compliance and vascular resistance. Dynamic compliance and vascular resistance of the control lungs or lungs subjected to deflation and reinflation (D/R) were measured. Data are expressed as the mean ± standard error of the mean of 6 lungs per group. *P < .05 compared with ventilated lungs (area under the curve, unpaired t test). Bas, Baseline.