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Study design comprising four different independent cohorts (MCIp - Methyl-CpG immunoprecipitation, DMR – differentially methylated region, MassARRAY® (technique by Sequenome) - matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS), CRT – chemoradiotherapy, RT – radiotherapy, GER – German cohort, FRA – French cohort)
