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. 2014 Aug 8;5(18):8466–8477. doi: 10.18632/oncotarget.2327

Figure 6. PIWIL2 induces F-actin filaments in tumor cells via c-Myc/RhoA pathway.

Figure 6

(A) PIWIL2 increases F-actin filaments in tumor cells. (B) PIWIL2 alters RhoA expression in a c-Myc-dependent manner. Transfected cells with indicated constructs were harvested for western blot analysis. (C) PIWIL2 induces F-actin stress fiber filaments via regulating c-Myc/RhoA pathway. (A) And (C) Transfected cells with indicated constructs were plated on coverslips for 24h prior to fixation, permeabilization, and staining for F-actin by TRITC-Phalloidine (Red), and then photoed via Olympus LSCM. Scale Bar, 20μm.