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. 2014 Aug 8;5(18):8478–8491. doi: 10.18632/oncotarget.2328

Figure 2. Dp44mT inhibits invasion and adhesion of cancer cells in vitro and inhibits metastasis in vivo through up-regulating NDRG2.

Figure 2

(A) Dp44mT increased the expression of NDRG2 significantly in HCC-LM3 cells. Cell invasion experiment results showed Dp44mT (10 μM) or NDRG2 overexpression significantly inhibited the invasive capacity of HCC-LM3 cells, and NDRG2 knockdown attenuated the Dp44mT-induced inhibition of invasion in HCC-LM3 cells. The results represent means ± SD of experiments performed in triplicate. (B) 24 hours after Dp44mT (10 μM) treatment, adhesion to matrix proteins were performed in HCC-LM3 cells (which infected with NDRG2 or shNDRG2). Adhering cells were quantified by CytoSelectTM Cell Adhesion Assay Kit. The results represent means ± SD of experiments performed in triplicate. (C) 4 weeks after Dp44mT treatment, lung tissues were harvested. Representative lung tissue sections from each group were shown (hematoxylin and eosin stain; magnification, × 40). The number of lung metastatic foci in each group was calculated.