Skip to main content
. 2014 Aug 8;5(18):8478–8491. doi: 10.18632/oncotarget.2328

Figure 5. gp130/STAT3 pathway is involved in mediating Dp44mT action, and combination of NDRG2 expression and p-STAT3 signal is a powerful predictor of poor clinical outcome in HCCs.

Figure 5

(A) 24 hours after indicated treatment (Dp44mT 10 μM), HCC cells were analyzed for the indicated protein by immunoblotting. β-actin was used as the internal control. (B) Cell invasion assay showed Dp44mT attenuated the IL-6 (20 ng/ml) induced invasive capacity in MHCC-97L cells. The results represent means ± SD of experiments performed in triplicate. (C) Dp44mT reduced IL-6-induced phosphorylation of STAT3 in MHCC-97L and SMMC-7721 cells. β-actin was used as the internal control. (D) Combination of NDRG2 and p-STAT3 enhanced correlation to clinical parameters and the significance for poor prognosis.