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(A) Schematic of in vivo bone marrow infection/reconstitution experiment. (B) Kaplan-Meyer curve of PIM+MYC in vivo experiment. Lethally irradiated FVB mice were injected with bone marrow cells expressing MYC and GFP, PIM1, PIM2, PIM3 or BCLxl. (C) Gross histology of PIM+MYC induced leukemia. Leukemia infiltrates spleen and liver; indicated with arrows (D) H&E stains of liver and spleen sections.
