Figure 7. Inhibiting expression of MYC at a pre-leukemic stage decreases the ability of PIM1, PIM2 or PIM3 to cause rapid leukemia onset.

(A) Schematic of Tet-O-MYC bone marrow transplantation and doxycycline treatment experiment. 18 days following injection mice were switched to doxycycline containing chow to de-induce the MYC transgene. Following 100 days on doxycycline chow, the mice were switched back to regular feed. (B) Kaplan-Meyer curve of mice showing the window of doxycycline treatment (C) Representative FACS data showing population of T-cells in bone marrow.