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. 2014 Aug 19;5(18):8716–8728. doi: 10.18632/oncotarget.2368

Figure 2. Evaluation of esophageal tumor formation using histological examination and micro animal PET imaging and its relationship with MDSC recruitment.

Figure 2

a. The body weights of animals that consumed drinking water containing the carcinogen 4-NQO or vehicle (propylene glycol, control). The data represent the means ± SEM of five animals per group at the indicated times. *, p<0.05. A representative image of mice 13 weeks after a 16-week 4-NQO treatment period is shown. b. Images of the gross lesions and pathological findings of tissue sections from the animals treated with 4-NQO or vehicle for 16 weeks that were followed for 12–14 weeks. Histological determinations included hyperplasia, papilloma, and invasive carcinoma. c. Representative PET images from the mice treated with 4-NQO and diagnosed with invasive carcinoma, compared with the control. The tumor-to-muscle SUVR was calculated from the micro-PET scans. d. Representative PET images from mice treated with 4-NQO and diagnosed with hyperplasia/papilloma or invasive carcinoma. The tumor-to-muscle SUVR was calculated from the micro-PET scans. Data points represent the means ± SEMs. *, p<0.05. e.Flow cytometric analysis of CD11b+Gr1+ cells from mice exhibiting hyperplasia/papilloma or invasive carcinoma after histological analysis. Representative images and quantitation are shown. The columns represent the means ± SEM. *, p<0.05.