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. 2014 Aug 19;5(18):8716–8728. doi: 10.18632/oncotarget.2368

Figure 3. Effect of MDSCs on tumor progression in vivo.

Figure 3

a. The infusion of MDSCs increased the SUVR of PET images in esophageal lesions of mice followed for 12–14 weeks after a 16-week 4-NQO treatment period. The tumor-to-muscle SUVR was calculated from the micro-PET scans. Data points represent the means ± SEMs. *, p<0.05 b. Flow cytometric analysis of CD11b+Gr1+ cells from the 4-NQO-treated mice with or without MDSC infusion. Representative images and quantitative data are shown. The columns represent the means ± SEM. *, p<0.05. c. Representative images of gross lesions and the pathological findings on sectioned tissue samples from the 4-NQO-treated mice with or without MDSC infusion. Quantitative data assessing the incidence of invasive esophageal tumors are shown. The columns represent the means ± SEM. *, p<0.05 d. MDSC infusion attenuated the accumulation of CD3+CD8+ cells (Green: CD3; Red: CD8) and increased CD31 and VEGF immunostaining. Representative images are shown.