Table 2. RNAseq analysis on PDX comparing 6 pairs of treated versus untreated samples.

Top Canonical Pathways	P-Value
Protein Kinase A Signaling	3.58E-05
GNRH Signaling	2.74E-04
Sphingosine-1-phosphate signaling	5.4E-04
α-Adrenergic signaling	9.39E-04
Cholecystokinin/Gastrin-mediated signaling	1.91E-03
Molecular and Cellular Functions
Lipid Metabolism	1.33E-04 to 3.80E-02
Molecular Transport	1.33E-04 to 3.80E-02
Small Molecule Biochemistry	1.33E-04 to 3.80E-02
Cell Morphology	1.64E-04 to 3.80E-02
Cellular Assembly and Organization	1.64E-04 to 3.75E-02
Top Up-Regulated Molecules	Fold-Change Expression
ZNF750	2.441
ACP5	2.294
HIST2H2BE	2.141
CPEB3	2.117
DNM3	2.028
MPC1	1.980
ABCG1	1.938
MGLL	1.924
TLR5	1.884
Top Down-Regulated Molecules	Fold-Change Expression
APOC1	-2.488
GPHA2	-2.262
POLR3G	-1.862
TES	-1.759
PLCE1	-1.738
PUS7	-1.618
ARNT2	-1.607
MECOM	-1.570
CKAP4	-1.564
KLF5	-1.554