Table 2. Statistics for each population separately for the single most abundant isomiR produced from a given precursor arm.
The most abundant isomiR's identity was determined by analyzing the collection of all unique datasets that passed quality control and belonged to the population under consideration (a total of 452 datasets; no technical replicates were included). At each locus, we also generated the “conservative” estimate (4th row) by requiring that the most abundant isomiR have higher expression than the miRBase reference by at least 0.585 log2 units.
| CEU | FIN | GBR | TSI | YRI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Percentage | Number | Percentage | Number | Percentage | Number | Percentage | Number | Percentage | |
| MiRNA precursor arms considered | 196 | 185 | 188 | 185 | 197 | |||||
| MiRBase miRNA sequence not among the 95-th percentile | 61 | 31% | 54 | 29% | 57 | 30% | 55 | 30% | 59 | 30% |
| Top isomiR not in agreement with miRBase | 95 | 48% | 87 | 47% | 92 | 49% | 90 | 49% | 93 | 47% |
| Top isomiR (conservative) not in agreement with miRBase | 85 | 43% | 79 | 43% | 84 | 45% | 81 | 44% | 83 | 42% |
| Top isomiR disagrees with miRBase at 5' end | 13 | 7% | 11 | 6% | 10 | 5% | 10 | 5% | 11 | 6% |
| Top isomiR disagrees with miRBase at 5' end only | 2 | 1% | 3 | 2% | 3 | 2% | 2 | 1% | 2 | 1% |
| Top isomiR disagrees with miRBase at 3' end | 93 | 47% | 84 | 45% | 89 | 47% | 88 | 48% | 91 | 46% |
| Top isomiR disagrees with miRBase at 3' end only | 82 | 42% | 76 | 41% | 82 | 44% | 80 | 43% | 82 | 42% |
| Top isomiR disagrees with miRBase at both ends | 11 | 6% | 8 | 4% | 7 | 4% | 8 | 4% | 9 | 5% |