Table 3. Multivariate Cox hazard models associated with overall or disease-specific survival.

Multivariate Cox models were generated using reverse-stepwise regression to select the independent prognostic variables for HNSCC survival in this patient cohort. The variables included in the final multivariate models were: HOXD10 Immunohistochemical positivity, patient age, tumor site and tumor stage. The UICC stage of the disease was also included in the disease-specific survival model.

Parameter	Overall Survival HR (95%CI)/p-value	Disease Related Survival HR (95%CI)/p-value
HOXD10 Negative Positive	REFERENCE 2.23 (1.22-4.09)/9.16×10-3	REFERENCE 2.62 (1.20-5.70)/1.51×10-2
Age < 57 years ≥ 57 years	REFERENCE 2.49 (1.43-4.33)/1.28×10-3	REFERENCE 2.62 (1.26-5.43)/9.86×10-3
Tumour Site Base of Tongue Oropharynx and Pharynx Retromolar Trigone Soft Palate Tonsil	p-value 0.41	p-value 0.011
T Stage Stage I Stage II Stage III Stage IV	REFERENCE 1.28 (0.64-2.56)/0.49 2.36 (0.91-6.08)/0.08 8.71 (3.22-23.55)/1.97×10-5	REFERENCE 1.43 (0.31-6.62)/0.65 4.99 (0.98-25.3)/0.05 8.06 (1.44-45.3)/0.02
UICC Stage Stage I Stage II Stage III Stage IV	—	REFERENCE 0.51 (0.06-4.28)/0.53 0.58 (0.09-3.82)/0.57 1.74 (0.29-10.62)/0.55