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. 2014 Nov 10;207(3):335–349. doi: 10.1083/jcb.201404097

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© 2014 Rošić et al.

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Figure 7. — Model for a role of SAT III RNA in centromere regulation. SAT III RNA interaction with CENP-C is required to stably localize CENP-C and therefore CENP-A to centromeres. Disruption of this process by SAT III knockdown impairs a stable association of CENP-C and CENP-A with centromeres and disrupts the formation of a functional kinetochore during mitosis. This in turn results in reduced chromosomal attachment to the spindle, lagging chromosomes, and general genome instability.