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. 2014 Nov 10;207(3):375–391. doi: 10.1083/jcb.201404016

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© 2014 Ogun and Zallocchi

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Clarin-1 regulates ciliogenesis. (A–D) Representative images of the kinocilia immunostained for acetylated tubulin (ac tub) in 3 dpf control (A), clarin-1 (Clrn1) MOs (B), MOs + cRNA (C), or cRNAΔCT (D). Hair cell bundle was counterstained with phalloidin. (E–H) Representative images of the ultrastructural analysis of the kinocilia in 3 dpf control (E), clarin-1 MOs (F), MOs + cRNA (G), or cRNAΔCT (H). Bar graph depicts kinocilium lengths for each treatment. Values correspond to the mean length of all the kinocilia per neuromast. Measurements were obtained from confocal (n > 5 independent experiments) and SEM images (n = 6 independent experiments) and expressed as means ± SEM. Total number of neuromasts analyzed, n > 10. Control MO = 18.4 ± 0.5 µm. Clrn1 MO = 13.8 ± 1.3 µm. Clrn1 MO + cRNA = 19.5 ± 1.1 µm. Clrn1 MO + cRNAΔCT = 18.0 ± 0.6 µm. **, P < 0.01 versus control MO. +++, P < 0.001 versus cRNA. ˄˄, P < 0.01 versus cRNAΔCT. Bars: (A–D) 7 µm; (E–H) 5 µm.