Table A2.

Multivariable Analysis, Relapse-Free Survival End Point

Covariate	HR	95% CI	P
Biochemotherapy (ref., HDI)	0.75	0.58 to 0.97	.03
Age 45 years or older (ref., age younger than 45 years)	1.00	0.77 to 1.30	1.00
Male (ref., female)	1.21	0.90 to 1.62	.21
Nodal involvement: any macro (ref., only micro)*	1.56	1.16 to 2.09	.003
No. of nodes: four or one with S/IT (ref., one to three or S/IT only)	1.54	1.14 to 2.09	.006
No ulceration (ref., ulceration)	0.58	0.43 to 0.79	< .001
Ulceration unknown (ref., ulceration)†	0.49	0.35 to 0.70	< .001

Abbreviations: HDI, high-dose interferon; HR, hazard ratio; ref., reference; S/IT, satellite/in-transit metastasis.

^*Macro, lymph node macrometastasis; micro, lymph node micrometastasis.

^†Unknown ulceration includes unknown primary.