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Pharmacokinetic parameter estimates and percent relative standard errors (%RSE) for AMG925, sorafenib and AC220
| Compound | Parameter (units) | Estimate (%RSE) |
|---|---|---|
| AMG925 | Km (nM) | 94.5 (7.9) |
| Vmax (nmol/h) | 4.16 (3.1) | |
| V (L) | 0.109 (7.4) | |
| ka (h−1) | 1.00 (20) | |
|
| ||
| Sorafenib | Km (nM) | 9.85 (19) |
| Vmax (nmol/h) | 0.0736 (12) | |
| V (L) | 0.0247 (4.4) | |
| ka (h−1) | 3 (Fixed) | |
|
| ||
| AC220 | kel (h−1) | 0.191 (5.6) |
| V (L) | 0.0964 (10) | |
| ka (h−1) | 1.37 (Fixed) | |
