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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2014 Oct 19;41(6):675–691. doi: 10.1007/s10928-014-9393-x

Table 5.

Parameter estimates and corresponding inter-animal variability (IIV as CV%) for the plasma PK-cellular signaling-tumor burden model with AMG925 orthotopic tumor studies

Parameter (units) Description Mean IIV CV%
λ0 (h−1) Exponential tumor growth rate 0.0439 (Fixed) -
λ1 (megaphotons/sec/h) Super-linear but sub-exponential growth rate 0.18 (Fixed) -
γ Factor determining the shape of tumor growth 0.257 (Fixed) -
IC50TS Inhibition fraction of pSTAT5 eliciting half of maximal tumor growth suppression 0.792 14.8
IC50TR Inhibition fraction of pSTAT5 eliciting half of maximal tumor growth suppression 2.38 14.4
HS Hill coefficient 15.1 37.6
HR Hill coefficient 14.9 20.1
BLI (0) (megaphotons/sec) Initial BLI level 4.19 20.1