. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2014 Oct 19;41(6):675–691. doi: 10.1007/s10928-014-9393-x

Table A.3.

The tumor burden study dosing regimens and observation schedules for AMG925 and sorafenib. In BID studies, the two doses each day were 6 hours apart.

Compound	Dosing Regimen	Dosing start time (hours)	Observation Times (hours)	Number of Animals
AMG925	BID 37.5 mg/Kg for 10 days	24	0, 48, 96, 144, 192, 240	10
	BID 25 mg/Kg for 10 days	24	0, 48, 96, 144, 192, 240	10
	BID 12.5 mg/Kg for 10 days	24	0, 48, 96, 144, 192, 240	10
	BID 6.25 mg/Kg for 10 days	24	0, 48, 96, 144, 192, 240	10
	BID Vehicle for 10 days	24	0, 48, 96, 144, 192, 240	10
	QD 150 mg/Kg for 8 days	48	24, 72, 120, 168, 216	10
	QD 75 mg/Kg for 8 days	48	24, 72, 120, 168, 216	10
	QD 50 mg/Kg for 8 days	48	24, 72, 120, 168, 216	10
	QD 25 mg/Kg for 8 days	48	24, 72, 120, 168, 216	10
	QD Vehicle for 8 days	48	24, 72, 120, 168, 216	10
Sorafenib	QD 10 mg/Kg for 10 days	24	24, 96, 168, 240	10
	QD 3 mg/Kg for 10 days	24	24, 96, 168, 240	10
	QD 1 mg/Kg for 10 days	24	24, 96, 168, 240	10
	QD 0.1 mg/Kg for 10 days	24	24, 96, 168, 240	9
	QD Vehicle for 10 days	24	24, 96, 168, 240	9