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Hematoxylin and eosin stained sections of colon (a–c) and small intestine (duodenum; d–f) from rats given D5W (a, d), irinotecan (b, e) or Irinophore C™ (c, f). All images obtained with 10X objective. Note the shortening and fusion of villi, loss of villar epithelium with flattening of remaining epithelia cells, dilation of villar lymphatics, edema of mucosal lamina propria and congestion of capillaries in irinotecan-treated rat sections (b, e). Bars indicate 200 μm
