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. 2014 Jul 27;32(6):1071–1082. doi: 10.1007/s10637-014-0138-x

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© The Author(s) 2014

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 4 — GI toxicity (diarrhea) score (a), total clinical observation scores (b) and body weight change as a percentage of weight on day 1 (c) for rats given saline (●), irinotecan at 150 mg/kg on days 1 and 2 plus 5-FU at 15 mg/kg days 1 and 2 or Irinophore C™ at 150 mg/kg days 1 and 2 plus 5-FU at 15 mg/kg on days 1 and 2 . Administrations are indicated by arrows. Symbols represent the means (±standard error) of 7–8 rats

Inline graphic — GI toxicity (diarrhea) score (a), total clinical observation scores (b) and body weight change as a percentage of weight on day 1 (c) for rats given saline (●), irinotecan at 150 mg/kg on days 1 and 2 plus 5-FU at 15 mg/kg days 1 and 2 or Irinophore C™ at 150 mg/kg days 1 and 2 plus 5-FU at 15 mg/kg on days 1 and 2 . Administrations are indicated by arrows. Symbols represent the means (±standard error) of 7–8 rats