Table 3.
Common lesions in AD, VaD, MIX, and aged controls (from[130])
| Pathological feature | AD [%] | VaD [%] | MIX [%] | Aged controls [%] |
|---|---|---|---|---|
| Cerebral amyloid angiopathy | 98 | 30 | ~90 | 23-45 |
| Small vessel disease/MVD | ~50 | >50 | >50 | ~20 |
| Total infarctions | 10-20 | 100 | 30-40 | >10 |
| Microinfarcts/lacunes | 30-46 | 70 | 60-70 | 17-21 |
| Intracerebral hemorrhage | 10-15 | 15 | 10 | 1-2 |
| White matter pathology | 40 | 80 | 70-80 | <20 |
| Loss of cholinergic markers | 75 | 40 | ~70 | |
| CVD/atherosclerosis | 45-60 | 60 | ~60 | 30-53 |
Abbreviations: AD, Alzheimer’s disease; CVD, Cerebrovascular disease; MIX, mixed type dementia (AD plus vascular dementia); MVD, Microvascular disease; VaD, Vascular dementia.