Table 3.
Summary of data - part II
| Group | E | A | B | C | D | F |
|---|---|---|---|---|---|---|
| Standard diet - control | Standard diet +0.25 g/day Lenziaren® | Standard diet +0.5 g/day Lenziaren® | Standard diet +1.0 g/day Lenziaren® | Standard diet +2.0 g/day Lenziaren® | Renal diet | |
| Phosphorus consumed (g/3 days) | ||||||
| Day −14 | 1.102 (0.323) | 1.203 (0.152) | 1.028 (0.344) | 1.186 (0.273) | 1.322 (0.390) | NA |
| Day 28 | 1.049 (0.286) | 1.202 (0.151) | 1.141 (0.320) | 1.213 (0.257) | 1.137 (0.311) | 0.567 (0.135) |
| CFB Day 28 from Day −14 | −0.053 (0.075) | −0.001 (0.001) | 0.113 (0.117) | 0.027 (0.132) | −0.185 (0.222) | NA |
| Mean Days 7-28 | 1.036 (0.282) | 1.189 (0.128) | 1.091 (0.281) | 1.230 (0.274) | 1.188 (0.296) | 0.555 (0.144) |
| CFB Mean Days 7–28 from Day −14 | −0.066 (0.100) | −0.014 (0.034) | 0.064 (0.103) | 0.044 (0.145) | −0.134 (0.207) | NA |
| Phosphorus excreted in faeces (g/3 days) | ||||||
| Day −14 | 0.708 (0.475) | 0.778 (0.260) | 0.694 (0.415) | 0.798 (0.318) | 0.735 (0.128) | NA |
| Day 28 | 0.810 (0.197) | 0.960 (0.222) | 0.888 (0.447) | 0.877 (0.304) | 0.730 (0.245) | 0.433 (0.085) |
| CFB Day 28 from Day −14 | 0.102 (0.390) | 0.182 (0.251) | 0.194 (0.375) | 0.080 (0.114) | −0.005 (0.165) | NA |
| Mean Days 7-28 | 0.716 (0.153) | 0.906 (0.205) | 0.819 (0.256) | 0.901 (0.268) | 0.809 (0.287) | 0.338 (0.075) |
| CFB Mean Days 7–28 from Day −14 | 0.008 (0.360) | 0.127 (0.165) | 0.125 (0.245) | 0.103 (0.131) | 0.074 (0.234) | NA |
| Phosphorus excreted in urine (g/3 days) | ||||||
| Day −14 | 0.257 (0.083) | 0.179 (0.134) | 0.295 (0.114) | 0.159 (0.060) | 0.240 (0.149) | NA |
| Day 28 | 0.390 (0.190) | 0.420 (0.120) | 0.321 (0.117) | 0.320 (0.148) | 0.166 (0.118) | 0.229 (0.091) |
| CFB Day 28 from Day −14 | 0.068 (0.132) | 0.163 (0.122) | 0.040 (0.055) | 0.167 (0.142) | −0.020 (0.086) | NA |
| Mean Days 7-28 | 0.353 (0.111) | 0.383 (0.105) | 0.320 (0.115) | 0.304 (0.109) | 0.204 (0.147) | 0.189 (0.049)) |
| CFB Mean Days 7–28 from Day −14 | 0.096 (0.089) | 0.204 (0.081) | 0.025 (0.058) | 0.144 (0.124) | −0.037 (0.098) | NA |
| Total phosphorus excreted (g/3 days) | ||||||
| Day −14 | 0.965 (0.549) | 0.958 (0.327) | 0.989 (0.522) | 0.957 (0.312) | 0.976 (0.204) | NA |
| Day 28 | 1.201 (0.331) | 1.380 (0.230) | 1.209 (0.490) | 1.197 (0.439) | 0.896 (0.328) | 0.661 (0.166) |
| CFB Day 28 from Day −14 | −0.011 (0.437) | 0.179 (0.188) | 0.145 (0.301) | 0.243 (0.235) | 0.123 (0.408) | NA |
| Mean Days 7-28 | 1.068 (0.247) | 1.289 (0.277) | 1.139 (0.354) | 1.205 (0.372) | 1.013 (0.405) | 0.526 (0.118) |
| CFB Mean Days 7–28 from Day −14 | 0.103 (0.370) | 0.331 (0.197) | 0.150 (0.245) | 0.247 (0.136) | 0.037 (0.261) | NA |
| Phosphorus balance (g/3 days) | ||||||
| Day −14 | 0.137 (0.283) | 0.245 (0.296) | 0.039 (0.245) | 0.229 (0.200) | 0.347 (0.254) | NA |
| Day 28 | −0.152 (0.208) | −0.178 (0.282) | −0.068 (0.348) | 0.016 (0.327) | 0.241 (0.192) | −0.094 (0.052) |
| CFB Day 28 from Day −14 | −0.288 (0.300) | −0.423 (0.262) | −0.106 (0.263) | −0.213 (0.240) | −0.106 (0.206) | NA |
| Mean Days 7-28 | −0.032 (0.197) | −0.100 (0.262) | −0.048 (0.171) | 0.025 (0.220) | 0.175 (0.177) | 0.029 (0.047) |
| CFB Mean Days 7–28 from Day −14 | −0.169 (0.369) | −0.345 (0.187) | −0.087 (0.165) | −0.204 (0.113) | −0.171 (0.341) | NA |
| Fractional urinary phosphate excretion (%) | ||||||
| Day −14 | 17.96 (4.47) | 16.57 (3.36) | 20.75 (4.63) | 19.64 (5.30) | 17.60 (4.71) | NA |
| Day 28 | 18.60 (7.21) | 17.91 (5.70) | 18.44 (5.71) | 15.17 (2.25) | 11.37 (3.71) | 16.97 (2.41) |
| CFB Day 28 from Day −14 | 0.63 (4.02) | 1.34 (4.15) | −2.32 (6.01) | −4.47 (5.22) | −6.23 (1.49) | NA |
| Mean Days 7-28 | 20.39 (6.68) | 19.18 (3.43) | 17.90 (4.34) | 17.25 (2.23) | 12.93 (5.09) | 15.27 (3.26) |
| CFB Mean Days 7–28 from Day −14 | 2.42 (3.36) | 2.61 (2.25) | −2.85 (4.43) | −2.39 (3.58) | −4.67 (2.16) | NA |
Data are mean (SD), CFB = change from baseline.
NA = not applicable.