Table 1.
Patient demographics
|
Characteristic |
All |
Persistent or nosocomial infection, |
No persistent or nosocomial infection |
P
a
|
|---|---|---|---|---|
| (n = 22) | (n = 6) | (n = 16) | ||
| Age, years |
1.3 [0.3–14] |
8 [0.9 – 16] |
0.9 [0.2–12] |
0.1 |
| Female gender, n (%) |
10 (45) |
2 (33) |
8 (50) |
0.6 |
| Complex chronic condition, n (%) |
8 (36) |
3 (50) |
5 (31) |
1 |
| Initial OFI ≥ 3, n (%)b |
10 (45) |
5 (83) |
5 (31) |
0.06 |
| Initial PRISM IIIb |
11.5 [9 – 14] |
10.5 [8.8 – 12.5] |
13 [8 – 16] |
0.4 |
| Initial PELODb |
12 [11 – 18] |
12 [1 – 14] |
12 [11 – 21] |
0.3 |
| Site of initial infection, n (%) |
|
|
|
|
| Culture negative |
4 (18) |
0 |
4 (25) |
|
| Blood |
4 (18) |
2 (33) |
2 (13) |
|
| Lung |
8 (36) |
3 (50) |
5 (31) |
|
| Urine |
2 (9) |
0 |
2 (13) |
|
| Abdomen |
1 (5) |
0 |
1 (6) |
|
| Multisite |
3 (14) |
1 (17) |
2 (13) |
|
| Glucocorticoid use, n (%)c |
|
|
|
|
| MP/Dex for < 24 hoursd |
8 (36) |
1 (17) |
7 (44) |
0.4 |
| MP/Dex for > 24 hours |
4 (18) |
3 (50) |
1 (6) |
0.046 |
| HCTZ for > 24 hoursd |
4 (18) |
0 |
4 (25) |
0.5 |
| Outcomes |
|
|
|
|
| ICU-free days in 28 days |
17 [10 – 21] |
5.5 [0–16] |
19.2 [15 – 22] |
0.05 |
| Mortality, n (%) | 2 (9) | 1 (17) | 1 (6) | 0.4 |
aPersistent or nosocomial infection versus no persistent or nosocomial infection (Mann–Whitney or Fisher Exact test). bValues at the time of sepsis onset. cGlucocorticoid use within 7 days of sepsis onset. dIncludes two patients treated with HCTZ and with MP/Dex for less than 24 hours. PRISM, Pediatric Risk of Mortality; PELOD, Pediatric Logistic Organ Dysfunction; OFI, Organ Failure Index; MP, methylprednisolone; Dex, dexamethasone; HCTZ, hydrocortisone. Data are median (IQR), except where otherwise specified.