Table 4.
Plasma metabolites detected in the sham-operated and model animals 45 days after the operation
| Metabolic pathway | RT (min) | Metabolites | Sham-operated (×10 9 ) | Model (×10 9 ) | P value |
|---|---|---|---|---|---|
| TAC |
19.6 |
Citric acid |
9.14 ± 7.010 |
1.91 ± 1.550▽ |
0.020 |
| 24.16 |
cAMP |
0.44 ± 0.200 |
0.13 ± 0.236▽ |
0.040 |
|
| Amino acid metabolism |
8.01 |
Ethylbis(trimethylsilyl)amine |
0.37 ± 0.124 |
0.69 ± 0.134▲ |
0.016 |
| 9.45 |
Alanine |
0.67 ± 0.250 |
0.41 ± 0.148▽ |
0.015 |
|
| 10.15 |
Silanamine |
2.34 ± 0.423 |
1.45 ± 0.537▽ |
0.041 |
|
| 10.91 |
L-Norvaline |
2.14 ± 0.473 |
1.02 ± 0.909▽ |
0.047 |
|
| 11.67 |
L-Valine |
0.29 ± 0.117 |
0.12 ± 0.032▽ |
0.014 |
|
| 12.00 |
Urea |
4.775 ± 0.851 |
6.96 ± 1.963▲ |
0.086 |
|
| 13.17 |
Glycine |
0.52 ± 0.154 |
0.24 ± 0.147▽ |
0.024 |
|
| 14.11 |
L-Serine |
1.17 ± 0.511 |
1.67 ± 0.266▲▲ |
0.001 |
|
| 16.15 |
L-Proline |
0.51 ± 0.104 |
0.36 ± 0.047▽ |
0.036 |
|
| Glucose metabolism |
20.02 |
Ribitol |
0.02 ± 0.053 |
0.35 ± 0.192▲▲ |
0.002 |
| 22.52 |
Glucopyranoside |
0.16 ± 0.046 |
0.07 ± 0.017▽ |
0.023 |
|
| Fatty acid metabolism |
8.73 |
Lactic acid |
1.27 ± 0.102 |
1.69 ± 0.319▲ |
0.039 |
| 14.80 |
Butanoic acid |
0.38 ± 0.080 |
0.52 ± 0.076▲ |
0.028 |
|
| 17.48 |
Dodecanoic acid |
0.56 ± 0.811 |
0.37 ± 0.209 |
0.550 |
|
| 21.78 |
Hexadecanoic acid |
2.45 ± 0.483 |
1.30 ± 0.707▽ |
0.023 |
|
| 23.19 |
Heneicosane |
0.74 ± 0.256 |
0.06 ± 0.181▽▽ |
0.000 |
|
| 23.53 |
Octadecanoic acid |
6.07 ± 0.927 |
4.28 ± 1.103▽ |
0.047 |
|
| 28.32 | Octadecatrienoic acid | 1.25 ± 0.149 | 0.48 ± 0.309▽▽ | 0.002 |
Note: ▲increased significantly in model group, P < 0.05 compare with the Sham Group, ▲▲P < 0.01 compare with the Sham Group; ▽decreased significantly in model group, P < 0.05 compare with the Sham Group, ▽▽P < 0.01 compare with the Sham Group.